Arizona Cardinals 15, San Francisco 49ers 16: final score and stats
San Francisco 49ers beat Arizona Cardinals, Arizona Cardinals 15 to San Francisco 49ers 16, on Sunday, September 21, 2025 at Levi's Stadium, Santa Clara, CA. Below: the box score, top performers, team stats, injuries and recent form for San Francisco 49ers vs Arizona Cardinals.
NFLSunday, September 21, 2025
DateSep 21, 2025
Start time4:25 PM ET
VenueLevi's Stadium, Santa Clara, CA
TVFox
Attendance70,414
Line score
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| Arizona Cardinals | 0 | 3 | 3 | 9 | 15 |
| San Francisco 49ers | 0 | 6 | 0 | 10 | 16 |
Team comparison
Arizona CardinalsSan Francisco 49ers
Points per game
Points allowed per game
2-1Record3-0
4th in NFC WestStanding1st in NFC West
3-3Road record / home record5-0
LWLWLLast 5WLWWW
L1StreakW1
Team stats
Arizona CardinalsSan Francisco 49ers
1st Downs
Passing 1st downs
Rushing 1st downs
1st downs from penalties
5-153rd down efficiency2-10
2-24th down efficiency1-2
Total Plays
Total Yards
Yards per Play
Total Drives
Passing
22/35Comp/Att27/41
Yards per pass
Interceptions thrown
1-5Sacks-Yards Lost1-2
Rushing
Injury report
Confirm lineups and injuries close to game time.
Arizona Cardinals
Hjalte Froholdt C · Concussion - Concussion
QuestionableJayden Williams OT · Knee - Not Specified
QuestionableAndrew Wingard S · Groin - Not Specified
QuestionableBam Knight RB · Concussion - Concussion
QuestionableDarius Robinson DE · Wrist - Not Specified
QuestionableSan Francisco 49ers
C.J. West DT · Knee - Not Specified
Injured ReserveTrent Williams OT · Shoulder - Not Specified
QuestionableDre Greenlaw LB · Knee - Not Specified
QuestionableMike Evans WR · Achilles - Tendinitis
QuestionableDeebo Samuel Sr. WR · Hamstring - Not Specified
QuestionableBox score
Arizona Cardinals Passing
| Player | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
|---|---|---|---|---|---|---|---|---|
| Kyler Murray | 22/35 | 159 | 4.5 | 1 | 0 | 1-5 | 53.0 | 82.9 |
| Team | 22/35 | 154 | 4.5 | 1 | 0 | 1-5 | -- | 82.9 |
Arizona Cardinals Rushing
| Player | CAR | YDS | AVG | TD | LONG |
|---|---|---|---|---|---|
| Trey Benson | 10 | 42 | 4.2 | 0 | 29 |
| Kyler Murray | 6 | 37 | 6.2 | 0 | 9 |
| James Conner | 9 | 22 | 2.4 | 0 | 9 |
| Greg Dortch | 1 | 5 | 5.0 | 0 | 5 |
| Emari Demercado | 2 | 0 | 0.0 | 0 | 1 |
| Team | 28 | 106 | 3.8 | 0 | 29 |
Arizona Cardinals Receiving
| Player | REC | YDS | AVG | TD | LONG | TGTS |
|---|---|---|---|---|---|---|
| Marvin Harrison Jr. | 3 | 44 | 14.7 | 0 | 32 | 6 |
| Trey McBride | 5 | 43 | 8.6 | 1 | 17 | 8 |
| Zay Jones | 2 | 25 | 12.5 | 0 | 18 | 3 |
| James Conner | 3 | 15 | 5.0 | 0 | 10 | 4 |
| Trey Benson | 3 | 9 | 3.0 | 0 | 5 | 4 |
| Tip Reiman | 2 | 8 | 4.0 | 0 | 6 | 3 |
| Elijah Higgins | 1 | 7 | 7.0 | 0 | 7 | 1 |
| Michael Wilson | 1 | 5 | 5.0 | 0 | 5 | 2 |
| Team | 22 | 159 | 7.2 | 1 | 32 | 34 |
Arizona Cardinals Fumbles
| Player | FUM | LOST | REC |
|---|---|---|---|
| James Conner | 1 | 0 | 0 |
| Hjalte Froholdt | 0 | 0 | 1 |
| Team | 1 | 0 | 1 |
Arizona Cardinals Defensive
| Player | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
|---|---|---|---|---|---|---|---|
| Mack Wilson Sr. | 12 | 6 | 0 | 1 | 2 | 0 | 0 |
| Akeem Davis-Gaither | 8 | 5 | 0 | 0 | 0 | 0 | 0 |
| Jalen Thompson | 6 | 4 | 0 | 0 | 0 | 0 | 0 |
| Budda Baker | 6 | 3 | 0 | 0 | 0 | 0 | 0 |
| Kei'Trel Clark | 5 | 3 | 0 | 0 | 0 | 0 | 0 |
| Dadrion Taylor-Demerson | 4 | 4 | 0 | 0 | 1 | 0 | 0 |
| Dalvin Tomlinson | 3 | 3 | 0 | 1 | 0 | 1 | 0 |
| Max Melton | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Team | 66 | 39 | 1 | 3 | 4 | 8 | 0 |
Arizona Cardinals Interceptions
| Player | INT | YDS | TD |
|---|---|---|---|
| Dadrion Taylor-Demerson | 1 | 18 | 0 |
| Team | 1 | 18 | 0 |
Arizona Cardinals KickReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Greg Dortch | 2 | 58 | 29.0 | 33 | 0 |
| Emari Demercado | 2 | 57 | 28.5 | 36 | 0 |
| Team | 4 | 115 | 28.8 | 36 | 0 |
Arizona Cardinals PuntReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Greg Dortch | 1 | 8 | 8.0 | 8 | 0 |
| Team | 1 | 8 | 8.0 | 8 | 0 |
Arizona Cardinals Kicking
| Player | FG | PCT | LONG | XP | PTS |
|---|---|---|---|---|---|
| Chad Ryland | 2/3 | 66.7 | 34 | 1/1 | 7 |
| Team | 2/3 | 66.7 | 34 | 1/1 | 7 |
Arizona Cardinals Punting
| Player | NO | YDS | AVG | TB | In 20 | LONG |
|---|---|---|---|---|---|---|
| Blake Gillikin | 5 | 258 | 51.6 | 1 | 2 | 55 |
| Team | 5 | 258 | 51.6 | 1 | 2 | 55 |
San Francisco 49ers Passing
| Player | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
|---|---|---|---|---|---|---|---|---|
| Mac Jones | 27/41 | 284 | 6.9 | 1 | 1 | 1-2 | 56.5 | 83.8 |
| Team | 27/41 | 282 | 6.9 | 1 | 1 | 1-2 | -- | 83.8 |
San Francisco 49ers Rushing
| Player | CAR | YDS | AVG | TD | LONG |
|---|---|---|---|---|---|
| Christian McCaffrey | 17 | 52 | 3.1 | 0 | 15 |
| Brian Robinson Jr. | 2 | 22 | 11.0 | 0 | 19 |
| Mac Jones | 1 | -1 | -1.0 | 0 | -1 |
| Team | 20 | 73 | 3.7 | 0 | 19 |
San Francisco 49ers Receiving
| Player | REC | YDS | AVG | TD | LONG | TGTS |
|---|---|---|---|---|---|---|
| Ricky Pearsall | 8 | 117 | 14.6 | 0 | 34 | 11 |
| Christian McCaffrey | 10 | 88 | 8.8 | 0 | 20 | 15 |
| Kendrick Bourne | 4 | 38 | 9.5 | 0 | 11 | 6 |
| Jake Tonges | 2 | 21 | 10.5 | 0 | 11 | 3 |
| Skyy Moore | 1 | 10 | 10.0 | 0 | 10 | 1 |
| Marquez Valdes-Scantling | 1 | 9 | 9.0 | 0 | 9 | 1 |
| Kyle Juszczyk | 1 | 1 | 1.0 | 1 | 1 | 1 |
| Team | 27 | 284 | 10.5 | 1 | 34 | 38 |
San Francisco 49ers Defensive
| Player | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
|---|---|---|---|---|---|---|---|
| Fred Warner | 11 | 5 | 0 | 0 | 2 | 0 | 0 |
| Dee Winters | 8 | 4 | 0 | 0 | 1 | 1 | 0 |
| Sam Okuayinonu | 7 | 2 | 0 | 0 | 0 | 0 | 0 |
| Marques Sigle | 7 | 2 | 0 | 0 | 0 | 0 | 0 |
| Upton Stout | 5 | 3 | 0 | 0 | 1 | 0 | 0 |
| Bryce Huff | 5 | 2 | 1 | 1 | 1 | 2 | 0 |
| Ji'Ayir Brown | 4 | 2 | 0 | 0 | 0 | 0 | 0 |
| Renardo Green | 4 | 1 | 0 | 0 | 0 | 0 | 0 |
| Team | 77 | 34 | 1 | 4 | 5 | 4 | 0 |
San Francisco 49ers KickReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Skyy Moore | 2 | 61 | 30.5 | 31 | 0 |
| Isaac Guerendo | 1 | 19 | 19.0 | 19 | 0 |
| Team | 3 | 80 | 26.7 | 31 | 0 |
San Francisco 49ers PuntReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Skyy Moore | 3 | 26 | 8.7 | 14 | 0 |
| Team | 3 | 26 | 8.7 | 14 | 0 |
San Francisco 49ers Kicking
| Player | FG | PCT | LONG | XP | PTS |
|---|---|---|---|---|---|
| Eddy Pineiro | 3/3 | 100.0 | 51 | 1/1 | 10 |
| Team | 3/3 | 100.0 | 51 | 1/1 | 10 |
San Francisco 49ers Punting
| Player | NO | YDS | AVG | TB | In 20 | LONG |
|---|---|---|---|---|---|---|
| Thomas Morstead | 3 | 128 | 42.7 | 0 | 2 | 48 |
| Team | 3 | 128 | 42.7 | 0 | 2 | 48 |
Recent form
Team pages
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Frequently asked questions
Who won Arizona Cardinals vs San Francisco 49ers?
San Francisco 49ers won, 16-15, on Sunday, September 21, 2025.
What was the final score of Arizona Cardinals vs San Francisco 49ers?
Arizona Cardinals 15, San Francisco 49ers 16.
Where is Arizona Cardinals vs San Francisco 49ers played?
Levi's Stadium, Santa Clara, CA.
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