San Francisco 49ers 48, Indianapolis Colts 27: final score and stats
San Francisco 49ers beat Indianapolis Colts, San Francisco 49ers 48 to Indianapolis Colts 27, on Monday, December 22, 2025 at Lucas Oil Stadium, Indianapolis, IN. Below: the box score, top performers, team stats, injuries and recent form for Indianapolis Colts vs San Francisco 49ers.
NFLMonday, December 22, 2025
DateDec 22, 2025
Start time8:15 PM ET
VenueLucas Oil Stadium, Indianapolis, IN
TVESPN/ABC
Attendance66,265
Line score
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| San Francisco 49ers | 14 | 10 | 10 | 14 | 48 |
| Indianapolis Colts | 7 | 10 | 3 | 7 | 27 |
Team comparison
San Francisco 49ersIndianapolis Colts
Points per game
Points allowed per game
11-4Record8-7
1st in NFC WestStanding3rd in AFC South
2-1Road record / home record1-3
WLWWWLast 5LLLLL
W1StreakL5
Team stats
San Francisco 49ersIndianapolis Colts
1st Downs
Passing 1st downs
Rushing 1st downs
1st downs from penalties
7-113rd down efficiency5-10
1-14th down efficiency0-1
Total Plays
Total Yards
Yards per Play
Total Drives
Passing
25/34Comp/Att23/36
Yards per pass
Interceptions thrown
1-0Sacks-Yards Lost2-23
Rushing
Injury report
Confirm lineups and injuries close to game time.
San Francisco 49ers
C.J. West DT · Knee - Not Specified
Injured ReserveDeommodore Lenoir CB · Foot - Not Specified
QuestionableRenardo Green CB · Back - Not Specified
QuestionableDeebo Samuel Sr. WR · Hamstring - Not Specified
QuestionableMike Evans WR · Achilles - Tendinitis
QuestionableIndianapolis Colts
Out
Arden Key DE · Hamstring - Not Specified
Injured ReserveA.J. Haulcy S · Ankle - Not Specified
QuestionableAkeem Davis-Gaither LB · Knee - Not Specified
QuestionableMo Alie-Cox TE · Groin - Not Specified
QuestionableBox score
San Francisco 49ers Passing
| Player | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
|---|---|---|---|---|---|---|---|---|
| Brock Purdy | 25/34 | 295 | 8.7 | 5 | 1 | 1-0 | 88.6 | 126.8 |
| Team | 25/34 | 295 | 8.7 | 5 | 1 | 1-0 | -- | 126.8 |
San Francisco 49ers Rushing
| Player | CAR | YDS | AVG | TD | LONG |
|---|---|---|---|---|---|
| Christian McCaffrey | 21 | 117 | 5.6 | 0 | 24 |
| Brian Robinson Jr. | 5 | 20 | 4.0 | 0 | 11 |
| Brock Purdy | 2 | 11 | 5.5 | 0 | 9 |
| Mac Jones | 3 | -3 | -1.0 | 0 | -1 |
| Team | 31 | 145 | 4.7 | 0 | 24 |
San Francisco 49ers Receiving
| Player | REC | YDS | AVG | TD | LONG | TGTS |
|---|---|---|---|---|---|---|
| George Kittle | 7 | 115 | 16.4 | 1 | 26 | 8 |
| Jauan Jennings | 5 | 71 | 14.2 | 1 | 21 | 6 |
| Christian McCaffrey | 6 | 29 | 4.8 | 2 | 10 | 8 |
| Kendrick Bourne | 3 | 27 | 9.0 | 0 | 14 | 5 |
| Demarcus Robinson | 2 | 23 | 11.5 | 1 | 22 | 2 |
| Skyy Moore | 1 | 23 | 23.0 | 0 | 23 | 1 |
| Jake Tonges | 1 | 7 | 7.0 | 0 | 7 | 2 |
| Brian Robinson Jr. | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Team | 25 | 295 | 11.8 | 5 | 26 | 33 |
San Francisco 49ers Fumbles
| Player | FUM | LOST | REC |
|---|---|---|---|
| Brock Purdy | 1 | 0 | 0 |
| Luke Farrell | 0 | 0 | 1 |
| Jake Tonges | 0 | 0 | 1 |
| Team | 1 | 0 | 2 |
San Francisco 49ers Defensive
| Player | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
|---|---|---|---|---|---|---|---|
| Ji'Ayir Brown | 9 | 5 | 0 | 1 | 0 | 0 | 0 |
| Tatum Bethune | 9 | 4 | 0 | 0 | 1 | 0 | 0 |
| Malik Mustapha | 8 | 3 | 0 | 0 | 0 | 1 | 0 |
| Darrell Luter Jr. | 6 | 5 | 0 | 0 | 1 | 0 | 0 |
| Upton Stout | 6 | 3 | 0 | 0 | 2 | 0 | 0 |
| Deommodore Lenoir | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Keion White | 3 | 1 | 0 | 0 | 0 | 1 | 0 |
| Dee Winters | 3 | 1 | 0 | 0 | 2 | 0 | 1 |
| Team | 67 | 31 | 2 | 3 | 7 | 4 | 1 |
San Francisco 49ers Interceptions
| Player | INT | YDS | TD |
|---|---|---|---|
| Dee Winters | 1 | 74 | 1 |
| Team | 1 | 74 | 1 |
San Francisco 49ers KickReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Skyy Moore | 4 | 112 | 28.0 | 36 | 0 |
| Brian Robinson Jr. | 2 | 55 | 27.5 | 31 | 0 |
| Team | 6 | 167 | 27.8 | 36 | 0 |
San Francisco 49ers PuntReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Skyy Moore | 1 | 8 | 8.0 | 8 | 0 |
| Team | 1 | 8 | 8.0 | 8 | 0 |
San Francisco 49ers Kicking
| Player | FG | PCT | LONG | XP | PTS |
|---|---|---|---|---|---|
| Eddy Pineiro | 2/3 | 66.7 | 38 | 6/6 | 12 |
| Team | 2/3 | 66.7 | 38 | 6/6 | 12 |
Indianapolis Colts Passing
| Player | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
|---|---|---|---|---|---|---|---|---|
| Philip Rivers | 23/35 | 277 | 7.9 | 2 | 1 | 2-23 | 52.2 | 97.0 |
| Riley Leonard | 0/1 | 0 | 0.0 | 0 | 0 | 0-0 | 2.2 | 39.6 |
| Team | 23/36 | 254 | 7.7 | 2 | 1 | 2-23 | -- | 94.3 |
Indianapolis Colts Rushing
| Player | CAR | YDS | AVG | TD | LONG |
|---|---|---|---|---|---|
| Jonathan Taylor | 16 | 46 | 2.9 | 1 | 7 |
| Tyler Goodson | 3 | 9 | 3.0 | 0 | 6 |
| Josh Downs | 1 | 3 | 3.0 | 0 | 3 |
| Team | 20 | 58 | 2.9 | 1 | 7 |
Indianapolis Colts Receiving
| Player | REC | YDS | AVG | TD | LONG | TGTS |
|---|---|---|---|---|---|---|
| Alec Pierce | 4 | 86 | 21.5 | 2 | 33 | 4 |
| Josh Downs | 5 | 65 | 13.0 | 0 | 18 | 9 |
| Jonathan Taylor | 3 | 33 | 11.0 | 0 | 19 | 3 |
| Michael Pittman Jr. | 4 | 32 | 8.0 | 0 | 14 | 5 |
| Tyler Warren | 3 | 30 | 10.0 | 0 | 19 | 9 |
| Mo Alie-Cox | 2 | 16 | 8.0 | 0 | 8 | 2 |
| Drew Ogletree | 1 | 11 | 11.0 | 0 | 11 | 2 |
| Ameer Abdullah | 1 | 4 | 4.0 | 0 | 4 | 1 |
| Team | 23 | 277 | 12.0 | 2 | 33 | 36 |
Indianapolis Colts Fumbles
| Player | FUM | LOST | REC |
|---|---|---|---|
| Ameer Abdullah | 1 | 1 | 0 |
| Philip Rivers | 1 | 0 | 0 |
| Danny Pinter | 0 | 0 | 1 |
| Team | 2 | 1 | 1 |
Indianapolis Colts Defensive
| Player | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
|---|---|---|---|---|---|---|---|
| Cam Bynum | 7 | 5 | 0 | 0 | 1 | 0 | 0 |
| Germaine Pratt | 6 | 4 | 0 | 0 | 1 | 0 | 0 |
| Nick Cross | 6 | 3 | 0 | 0 | 0 | 0 | 0 |
| DeForest Buckner | 5 | 4 | 0 | 0 | 0 | 0 | 0 |
| Cameron Mitchell | 4 | 4 | 0 | 1 | 0 | 0 | 0 |
| Samson Ebukam | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Zaire Franklin | 4 | 2 | 0 | 0 | 1 | 0 | 0 |
| Laiatu Latu | 3 | 3 | 1 | 1 | 0 | 1 | 0 |
| Team | 66 | 46 | 1 | 3 | 5 | 1 | 0 |
Indianapolis Colts Interceptions
| Player | INT | YDS | TD |
|---|---|---|---|
| Cam Bynum | 1 | 8 | 0 |
| Team | 1 | 8 | 0 |
Indianapolis Colts KickReturns
| Player | NO | YDS | AVG | LONG | TD |
|---|---|---|---|---|---|
| Coleman Owen | 3 | 89 | 29.7 | 33 | 0 |
| Tyler Goodson | 2 | 60 | 30.0 | 31 | 0 |
| Ameer Abdullah | 1 | 17 | 17.0 | 17 | 0 |
| Team | 6 | 166 | 27.7 | 33 | 0 |
Indianapolis Colts Kicking
| Player | FG | PCT | LONG | XP | PTS |
|---|---|---|---|---|---|
| Blake Grupe | 2/2 | 100.0 | 51 | 3/3 | 9 |
| Team | 2/2 | 100.0 | 51 | 3/3 | 9 |
Indianapolis Colts Punting
| Player | NO | YDS | AVG | TB | In 20 | LONG |
|---|---|---|---|---|---|---|
| Rigoberto Sanchez | 2 | 101 | 50.5 | 0 | 1 | 54 |
| Team | 2 | 101 | 50.5 | 0 | 1 | 54 |
Recent form
Team pages
Frequently asked questions
Who won San Francisco 49ers vs Indianapolis Colts?
San Francisco 49ers won, 48-27, on Monday, December 22, 2025.
What was the final score of San Francisco 49ers vs Indianapolis Colts?
San Francisco 49ers 48, Indianapolis Colts 27.
Where is San Francisco 49ers vs Indianapolis Colts played?
Lucas Oil Stadium, Indianapolis, IN.
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